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The Journal of Alternative and Complementary Medicine
The Association Between the DRD2 TaqI A Polymorphism and Smoking Cessation in Response to Acupuncture in Koreans
To cite this article:
Hi-Joon Park, Seung-Tae Kim, Dong-Hak Yoon, Soo Hee Jin, Su-Jin Lee, Hye Jung Lee, Sabina Lim.
The Journal of Alternative and Complementary Medicine.
June 2005,
11(3): 401-405.
doi:10.1089/acm.2005.11.401.
Hi-Joon Park, K.M.D., Ph.D.Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea. Seung-Tae Kim, K.M.D., M.A.Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea. Dong-Hak Yoon, K.M.D., Ph.D.Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea. Soo Hee Jin, M.A.Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea. Su-Jin Lee, B.A.Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea. Hye Jung Lee, K.M.D., Ph.D.Department of Oriental Medial Science, Graduate School of East–West Medical Science, Kyung Hee University, Kyungki-do, South Korea. Sabina Lim, K.M.D., Ph.D.Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea. Objectives: The response to acupuncture is presumed to differ with the individual; this variation might be due to genetic differences. Therefore, we examined whether the DRD2 TaqI A polymorphism is associated with the response to acupuncture in the treatment of smoking cessation in a Korean population. Subjects: A total of 231 healthy Korean male smokers participated in this study. Interventions: The subjects underwent three manual auricular acupuncture treatments in one week. Design and outcome measures: After 1 week, high and low responders to the acupuncture treatment were selected according to their cigarette consumption and the desire to smoke. A DRD2 TaqI A restriction enzyme fragment length polymorphism (RFLP) study examined genomic DNA extracted from blood samples. Results: The proportions of high, intermediate, and low responders were 28.6, 55.4, and 16.0%, respectively. The RFLP study showed that the distribution of the DRD2*A genotype and allele frequencies differed significantly between the high and low responders (X 2 test, p = 0.031 and 0.016, respectively), and that high responders had a higher DRD2*A2 allele frequency than low responders. Conclusions: Our findings suggest that DRD2 TaqI A polymorphism is related to acupuncture response in smoking cessation treatment.  This paper was cited by:Temperament and Character Profiles of Sasang Typology in an Adult Clinical Sample S. H. Park, M.-g. Kim, S. J. Lee, J. Y. Kim, H. Chae Evidence-based Complementary and Alternative Medicine. May 2009 CrossRef |
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