|
The Journal of Alternative and Complementary Medicine
Alzheimer's Disease Drug Discovery from Herbs: Neuroprotectivity from β-Amyloid (1-42) Insult
To cite this article:
Darrick S.H.L. Kim, Jin-Yung Kim, Ye Sun Han.
The Journal of Alternative and Complementary Medicine.
April 2007,
13(3): 333-340.
doi:10.1089/acm.2006.6107.
Darrick S.H.L. Kim, Ph.D.CurXceL Corporation, The Business and Technology Center, West Lafayette, IN. Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL. Jin-Yung Kim, Ph.D.CurXceL Corporation, The Business and Technology Center, West Lafayette, IN. Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL. Natural Science Research Institute, Seoul Woman's University, Seoul, Korea. Ye Sun Han, Ph.D.Department of Technology Fusion, Konkuk University, Seoul, Korea. Objective: To comparatively evaluate selected herbs for their ability to protect neuronal cells from direct βA(1-42) insult. Design: Twenty-seven (27) herbs were selected, extracted with aqueous methanol (90%) and chloroform, and the extracts were evaluated for their ability to protect PC12 rat pheochromocytoma and primary neuronal cells from βA(1-42) insult using both 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide reduction assay and lactate dehydrogenase efflux assay. Results: Curcuma aromatia (ul-keum) and Zingiber officinale (ginger) extracts effectively protected cells from βA(1-42) insult, followed by Ginkgo biloba (ginkgo), Polygonatum sp. (King Solomon's seal), Cinnamum cassia (Chinese cinnamon), Rheum coreanum (Korean rhubarb), Gastrodia elata (gastrodia), and Scutellaria baicalensis (skullcap). Several extracts showed cytotoxicity at high concentration ( 150 μg/mL), whereas other extracts did not at all protect cells from βA(1-42) insult. Conclusion: Selective herbs may be potentially important resources to discover drug candidates against the onset of Alzheimer's disease.  This paper was cited by:Herbal medicine for dementia: a systematic review Brian H. May, M. Lit, Charlie C. L. Xue, Angela W. H. Yang, Anthony L. Zhang, Michael D. Owens, Richard Head, Lynne Cobiac, Chun Guang Li, Helmut Hugel, David F. Story Phytotherapy Research. Feb 2008: n/a-n/a CrossRef Utilization of Ayurveda in Health Care: An Approach for Prevention, Health Promotion, and Treatment of Disease. Part 1—Ayurveda, the Science of Life Hari Sharma, H.M. Chandola, Gurdip Singh, Gopal Basisht The Journal of Alternative and Complementary Medicine. Nov 2007, Vol. 13, No. 9: 1011-1020 Abstract | Full Text PDF | Reprints & Permissions |
|
TOC Alert
CiteULike
Delicious
Digg This
Facebook
Newsvine