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AIDS Research and Human Retroviruses
Characterization of a Long Terminal Repeat Region from an Infectious Indian HIV Type 2 Isolate
To cite this article:
Mayur Tamhane, Rita Mukhopadhyaya, Robin Mukhopadhyaya.
AIDS Research and Human Retroviruses.
June 2005,
21(6): 592-596.
doi:10.1089/aid.2005.21.592.
Published in Volume: 21 Issue 6: June 30, 2005
Mayur Tamhane Virology Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Kharghar, Navi Mumbai-410 208, India. Present address: Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523. Rita Mukhopadhyaya Molecular Biology Division, BARC, Mumbai, India. Robin Mukhopadhyaya Virology Laboratory, Tata Memorial Centre, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Kharghar, Navi Mumbai-410 208, India. An infectious Indian human immunodeficiency virus type 2 isolate from Mumbai, propagated in this laboratory, was found to bear an unusually short long terminal repeat (LTR) region. Complete sequencing of the 601 bp LTR indicated a loss of around 250 nucleotide pairs from the unique 3' (U3) region as compared to other well-characterized HIV-2 isolates. Phylogenetic analysis of this LTR shows closest relatedness to the Guinea-Bissau subtype A isolates HIV-2CAM2 and HIV-2ALI. The LTR from the biologically active infectious clone with the observed deletion contained all functionally relevant promoter and polyadenylation sequences. This paper was cited by:Full-Length Genome Characterization of an HIV Type 2 Isolate from India C. V. Santhosh, Mayur C. Tamhane, Rita Mukhopadhyaya, Robin Mukhopadhyaya AIDS Research and Human Retroviruses. Oct 2008, Vol. 24, No. 10: 1315-1317 Abstract | Full Text PDF | Reprints & Permissions |
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