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AIDS Research and Human Retroviruses
Molecular Epidemiology of the Heterosexual HIV-1 Transmission in Kunming, Yunnan Province of China Suggests Origin from the Local IDU Epidemic
To cite this article:
Xiao-Jie Li, Shigeru Kusagawa, Xueshan Xia, Chaojun Yang, Qianqiu Wang, Yuko Yokota, Yoshimi Hoshina, Toshinari Onogi, Kyoko Nohtomi, Yuko Imamura, Teiichiro Shiino, Rongge Yang, Naoki Yamamoto, Kunlong Ben, Yutaka Takebe.
AIDS Research and Human Retroviruses.
November 2005,
21(11): 977-980.
doi:10.1089/aid.2005.21.977.
Xiao-Jie Li Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Institute of Dermatology, Chinese Academy of Medical Sciences, 12 Jiangwangmiao Road, Nanjing 210042, The People's Republic of China. Shigeru Kusagawa Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Xueshan Xia Kunming University of Science and Technology, Kunming, Yunnan 650224, The People's Republic of China. Chaojun Yang Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Yunnan Provincial Health and Anti-epidemic Center, 158 Dongsi Road, Kunming 650022, The People's Republic of China. Qianqiu Wang Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Institute of Dermatology, Chinese Academy of Medical Sciences, 12 Jiangwangmiao Road, Nanjing 210042, The People's Republic of China. Yuko Yokota Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Yoshimi Hoshina Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Toshinari Onogi Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Kyoko Nohtomi Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Yuko Imamura Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Teiichiro Shiino Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Rongge Yang Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Naoki Yamamoto Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Kunlong Ben Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, The People's Republic of China. Kunming Chinaware Biotechnology, Yunnan 650106, The People's Republic of China. Yutaka Takebe Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Molecular epidemiological investigation was conducted among injecting drug users (IDUs) (n = 11) and heterosexuals (n = 15) in Kunming, Yunnan Province of China. HIV-1 genotypes were determined based on the nucleotide sequences of 2.6-kb gag-RT region. The distribution of genotypes among IDUs was as follows: CRF07_BC (5/11) and CRF08_BC (5/11); subtype B' (1/11). Similarly, a majority of Kunming heterosexuals (14/15) were infected with CRF07_BC (4/15), CRF08_BC (6 /15), or subtype B' (4/15), known to predominate among IDUs in China. This contrasts with trends in the coastal regions of China and surrounding southeastern Asian countries, where CRF01_AE predominates among heterosexuals. The heterosexual HIV-1 epidemic in Kunming thus appears to derive from the local IDU epidemic. Of note, subtype B' was the most prevalent strain among heterosexuals before 1997, while CRF07_BC and CRF08_BC became predominant in 2002, indicating a transition of HIV-1 genotype distribution between the early and the more recent samples from Kunming heterosexuals.  This paper was cited by:Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China Yuan-Quan Tu, Min-Jie Wang, Jun Yao, Xiang-Ming Zhu, Pin-Liang Pan, Wen-Ge Xing, Gao-Hong Zhang, Rong-Ge Yang, Yong-Tang Zheng, Yan Jiang Transfusion. 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