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The relationships between host immune factors and HIV-1 disease progression are still in dispute. Unlike CCR5Δ32, which has been found to delay disease progression of HIV-1, there still remain several factors whose effect on the clinical course is unconfirmed. To clarify the relationships, we selected seven single-nucleotide polymorphisms (SNPs) out of the previously reported factors, namely, RANTES promoter −28G/−403A, RANTES In1.1C, SDF-1 3′A, IL-4 promoter −589T, and DC-SIGN promoter −139C/−336C, and examined these in Japanese HIV-1-infected hemophiliacs (n = 102). The genotypes were examined by the direct sequencing method, and the distributions of genotype and allelic frequencies were compared between two groups, slow progressors (n = 54) who did not develop AIDS more than 10 years after intravenous infection and others (progressors) (n = 48). The allelic frequency of RANTES −28G was significantly higher in slow progressors (0.185) than in the progressor group (0.074) [p = 0.023, OR = 0.35, 95% CI (0.142, 0.880)]. DC-SIGN promoter −139C, and appeared in progressors with significantly higher allelic frequency (0.333) than slow progressors [0.204, p = 0.040, OR = 1.95, 95% CI (1.039, 3.677)]. With RANTES −403A, RANTES In1.1C, SDF-1 3′ A, IL-4 −589T, and DC-SIGN −336C, no significant difference was observed in allelic frequencies between the two groups. These results suggest that RANTES −28G was associated with delayed AIDS progression, while DC-SIGN −139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs.