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Antioxidants & Redox Signaling
Discordant Response of Glutathione and Thioredoxin Systems in Human Hypertension?
To cite this article:
Maria L. Mansego, Sebastian Blesa, Veronica Gonzalez-Albert, Maria C. Tormos, Guillermo Saez, Josep Redon, Felipe J. Chaves.
Antioxidants & Redox Signaling.
2007,
9(4): 507-514.
doi:10.1089/ars.2006.1472.
Maria L. Mansego Laboratorio de Estudios Genéticos. Fundación para la Investigación del Hospital Clínico, Valencia, Spain. Sebastian Blesa Laboratorio de Estudios Genéticos. Fundación para la Investigación del Hospital Clínico, Valencia, Spain. Veronica Gonzalez-Albert Laboratorio de Estudios Genéticos. Fundación para la Investigación del Hospital Clínico, Valencia, Spain. Maria C. Tormos Department of Biochemistry and Molecular Biology of the Medical School, Valencia, Spain. Guillermo Saez Department of Biochemistry and Molecular Biology of the Medical School, Valencia, Spain. Josep Redon Hypertension Clinic, Hospital Clínico Universitario de Valencia, Valencia, Spain. Felipe J. Chaves, PhDLaboratorio de Estudios Genéticos. Fundación para la Investigación del Hospital Clínico, Valencia, Spain. Hypertension is frequently associated with oxidative stress caused by high production of reactive oxygen species and compromised antioxidant defenses. Humans with essential hypertension, with or without treatment, and controls were examined (35 hypertensive and 30 normotensive). We noted a discordant response of the glutathione and thioredoxin systems in essential hypertension and to antihypertensive treatment. Further studies examining the significance of these thiols in hypertension outcomes are warranted. This paper was cited by:Targeting Reactive Oxygen Species in Hypertension Christian Delles, William H. Miller, Anna F. Dominiczak Antioxidants & Redox Signaling. Jun 2008, Vol. 10, No. 6: 1061-1078 Abstract | Full Text PDF | Reprints & PermissionsThioredoxin in Vascular Biology: Role in Hypertension Talin Ebrahimian, Rhian M. Touyz Antioxidants & Redox Signaling. Jun 2008, Vol. 10, No. 6: 1127-1136 Abstract | Full Text PDF | Reprints & Permissions |
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