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Journal of Child and Adolescent Psychopharmacology
The Psychosis Prodrome in Adolescent Patients Viewed Through the Lens of DSM-IV
To cite this article:
Stephanie E. Meyer, Carrie E. Bearden, Sabrina R. Lux, Jamie L. Gordon, Jennifer K. Johnson, Mary P. O'Brien, Tara A. Niendam, Rachel L. Loewy, Joseph Ventura, Tyrone D. Cannon.
Journal of Child and Adolescent Psychopharmacology.
2005,
15(3): 434-451.
doi:10.1089/cap.2005.15.434.
Stephanie E. Meyer, Ph.D.Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California—Los Angeles, Los Angeles, California. Department of Psychology, University of California—Los Angeles, Los Angeles, California. Carrie E. Bearden, Ph.D.Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California—Los Angeles, Los Angeles, California. Sabrina R. Lux, B.A.Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California—Los Angeles, Los Angeles, California. Jamie L. Gordon, M.A.Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California—Los Angeles, Los Angeles, California. Jennifer K. Johnson, Ph.D.Department of Psychology, University of California—Los Angeles, Los Angeles, California. Mary P. O'Brien, Ph.D.Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California—Los Angeles, Los Angeles, California. Tara A. Niendam, M.A.Department of Psychology, University of California—Los Angeles, Los Angeles, California. Rachel L. Loewy, M.A.Department of Psychology, University of California—Los Angeles, Los Angeles, California. Joseph Ventura, Ph.D.Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California—Los Angeles, Los Angeles, California. Tyrone D. Cannon, Ph.D.Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and Hospital, University of California—Los Angeles, Los Angeles, California. Department of Psychology, University of California—Los Angeles, Los Angeles, California. Objective: Recently developed research criteria have made it possible to identify adolescents at imminent risk for psychosis. However, the array of symptomatology in these patients is broad and has not yet been systematically characterized using established diagnostic and assessment tools. Method: The authors characterized 24 adolescent research participants at the UCLA Center for the Assessment and Prevention of Prodromal States (CAPPS) using structured interviews for the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, (DSM-IV), the Child Behavior Checklist (CBCL), and information regarding psychiatric treatment histories. Two composite cases are also presented. Results: The most common DSM-IV diagnosis at study entry was major depression, followed by anxiety disorder not otherwise specified (NOS), and social phobia. Most participants met criteria for at least one subthreshold condition, including obsessive-compulsive disorder (OCD), psychosis, mania or hypomania, and generalized anxiety. CBCL data revealed high rates of affective disturbance and broad-ranging symptomatology, as did participants' diagnostic and treatment histories. Conclusions: Consistent with retrospective studies of patients with first-episode psychosis, findings revealed frequent mood and anxiety disturbance during the prodromal phase of illness. The DSM-IV does not offer a clear framework for describing the widespread subthreshold symptomatology that characterizes putatively prodromal patients. The authors consider whether the psychosis prodrome merits designation as a recognized clinical entity.  This paper was cited by:Early psychosis intervention service for children and youth: a retrospective chart review of the first four years Ashley Morris, Mary K. Nixon, Randy Keyes, Douglas Ashmore Early Intervention in Psychiatry. Jun 2009, Vol. 3, No. 2: 99-107 CrossRef Validity of the Prodromal Risk Syndrome for First Psychosis: Findings From the North American Prodrome Longitudinal Study S. W. Woods, J. Addington, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, R. Heinssen, D. O. Perkins, L. J. Seidman, M. T. Tsuang, E. F. Walker, T. H. McGlashan Schizophrenia Bulletin. May 2009 CrossRef Intervention in the at-risk state to prevent transition to psychosis Stephan Ruhrmann, Frauke Schultze-Lutter, Joachim Klosterkötter Current Opinion in Psychiatry. Apr 2009, Vol. 22, No. 2: 177-183 CrossRef Signs and symptoms in the pre-psychotic phase: description and implications for diagnostic trajectories S. N. Iyer, L. Boekestyn, C. M. Cassidy, S. King, R. Joober, A. K. Malla Psychological Medicine. Sep 2008, Vol. 38, No. 08 CrossRef Emotion Processing in Persons at Risk for Schizophrenia L. K. Phillips, L. J. Seidman Schizophrenia Bulletin. Aug 2008, Vol. 34, No. 5: 888-903 CrossRef Comorbid depressive symptoms in the developmental course of adolescent-onset psychosis Marina Myles-Worsley, Starla Weaver, Francisca Blailes Early Intervention in Psychiatry. Jun 2007, Vol. 1, No. 2: 183-190 CrossRef Neuroprotection in emerging psychotic disorders Gregor Berger, Margaret Dell?Olio, Paul Amminger, Barbara Cornblatt, Lisa Phillips, Alison Yung, Yung Yan, Michael Berk, Patrick McGorry Early Intervention in Psychiatry. Jun 2007, Vol. 1, No. 2: 114-127 CrossRef Phenomenology and diagnosis of bipolar disorder in children, adolescents, and adults: Complexities and developmental issues GABRIELLE A. CARLSON, STEPHANIE E. MEYER Development and Psychopathology. Jan 2007, Vol. 18, No. 04 CrossRef Self-reported psychopathology, adaptive functioning and sense of coherence, and psychiatric diagnosis among young men Terja Ristkari, Andre Sourander, John Ronning, Hans Helenius Social Psychiatry and Psychiatric Epidemiology. Aug 2006, Vol. 41, No. 7: 523-531 CrossRef Prospective investigations of the prodromal state of schizophrenia: review of studies K. A. Olsen, B. Rosenbaum Acta Psychiatrica Scandinavica. May 2006, Vol. 113, No. 4: 247-272 CrossRef |
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