Hello. Sign in to personalize your visit. New user? Register now.  
Open Access 12 months after Publication
Journal of Computational Biology
A Construction of Pooling Designs with Some Happy Surprises

To cite this article:
A. D'Yachkov, Frank Hwang, Antony Macula, Pavel Vilenkin, Chih-Wen Weng. Journal of Computational Biology. October 2005, 12(8): 1129-1136. doi:10.1089/cmb.2005.12.1129.

Published in Volume: 12 Issue 8: October 21, 2005

Full Text: • PDF for printing (55.8 KB) • PDF w/ links (89.1 KB)


A. D'Yachkov
Department of Probability Theory, Faculty of Mechanics and Mathematics, Moscow State University, Moscow, 119992, Russia.
Frank Hwang
Department of Applied Mathematics, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu 30050, Taiwan. This research was partially supported by a Republic of China NSC grant 92-2115-M-009-014.
Antony Macula
Department of Probability Theory, Faculty of Mechanics and Mathematics, Moscow State University, Moscow, 119992, Russia.
Department of Mathematics, College at Geneseo, State University of New York, Geneseo, NY 14454, USA. This research was partially supported by NSF-DMS 0107179.
Pavel Vilenkin
Department of Probability Theory, Faculty of Mechanics and Mathematics, Moscow State University, Moscow, 119992, Russia.
Chih-Wen Weng
Department of Applied Mathematics, National Chiao Tung University, 1001 Ta Hsueh Road, Hsinchu 30050, Taiwan. This research was partially supported by a Republic of China NSC grant 91-2005-M-009-008.

The screening of data sets for "positive data objects" is essential to modern technology. A (group) test that indicates whether a positive data object is in a specific subset or pool of the dataset can greatly facilitate the identification of all the positive data objects. A collection of tested pools is called a pooling design. Pooling designs are standard experimental tools in many biotechnical applications. In this paper, we use the (linear) subspace relation coupled with the general concept of a "containment matrix" to construct pooling designs with surprisingly high degrees of error correction (detection.) Error-correcting pooling designs are important to biotechnical applications where error rates often are as high as 15%. What is also surprising is that the rank of the pooling design containment matrix is independent of the number of positive data objects in the dataset.

Free first page

This paper was cited by:

Error-correcting pooling designs associated with the dual space of unitary space and ratio efficiency comparison
Geng-sheng Zhang, Xiao-lei Sun, Bo-li Li
Journal of Combinatorial Optimization. Aug 2009, Vol. 18, No. 1: 51-63
CrossRef
Weighted Superimposed Codes and Constrained Integer Compressed Sensing
Wei Dai, Olgica Milenkovic
IEEE Transactions on Information Theory. Jun 2009, Vol. 55, No. 5: 2215-2229
CrossRef
Two new error-correcting pooling designs from d-bounded distance-regular graphs
Xinlu Zhang, Jun Guo, Suogang Gao
Journal of Combinatorial Optimization. May 2009, Vol. 17, No. 3: 339-345
CrossRef
Constructing error-correcting pooling designs with symplectic space
Jun Guo, Yuexuan Wang, Suogang Gao, Jiangchen Yu, Weili Wu
Journal of Combinatorial Optimization. Mar 2009
CrossRef
Two constructions of new error-correcting pooling designs from orthogonal spaces over a finite field of characteristic 2
Zengti Li, Suogang Gao, Hongjie Du, Feng Zou, Weili Wu
Journal of Combinatorial Optimization. Feb 2009
CrossRef
New error-correcting pooling designs associated with finite vector spaces
Jizhu Nan, Jun Guo
Journal of Combinatorial Optimization. Jan 2009
CrossRef
The arrangement of subspaces in the orthogonal spaces and tighter analysis of an error-tolerant pooling design
Geng-Sheng Zhang, Yu-Qin Yang
Journal of Combinatorial Optimization. Jan 2009
CrossRef
Pooling designs associated with unitary space and ratio efficiency comparison
Jun Guo
Journal of Combinatorial Optimization. Oct 2008
CrossRef
On a hyperplane arrangement problem and tighter analysis of an error-tolerant pooling design
Hung Q. Ngo
Journal of Combinatorial Optimization. Feb 2008, Vol. 15, No. 1: 61-76
CrossRef
All articles
Previous Next