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Human Gene Therapy
Helper-Dependent Adenoviral Vectors for Gene Therapy
To cite this article:
Donna J. Palmer, Philip NG.
Human Gene Therapy.
January 2005,
16(1): 1-16.
doi:10.1089/hum.2005.16.1.
Donna J. Palmer Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030. Dr. Philip NG Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030. Helper-dependent adenoviral vectors possess a number of characteristics that make them attractive gene therapy vectors. These vectors are completely devoid of viral coding sequences and are able to mediate high-efficiency transduction in vivo to direct sustain high-level transgene expression with negligible chronic toxicity. This review focuses on advances in helper-dependent adenoviral vector technology, selected examples of in vivo studies of particular interest, and the issue of vector-mediated acute toxicity.  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