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Human Gene Therapy
Neurodegeneration Augments the Ability of Bone Marrow-Derived Mesenchymal Stem Cells to Fuse with Purkinje Neurons in Niemann–Pick Type C Mice
To cite this article:
Jae-Sung Bae, Shigeki Furuya, Yoko Shinoda, Shogo Endo, Edward H. Schuchman, Yoshio Hirabayashi, Hee Kyung Jin.
Human Gene Therapy.
August 2005,
16(8): 1006-1011.
doi:10.1089/hum.2005.16.1006.
Jae-Sung Bae College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, South Korea. Shigeki Furuya Neuronal Circuit Mechanisms Research Group, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Yoko Shinoda Neuronal Circuit Mechanisms Research Group, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Shogo Endo Laboratory for Learning and Memory, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Edward H. Schuchman Department of Human Genetics and Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029. Yoshio Hirabayashi Neuronal Circuit Mechanisms Research Group, RIKEN Brain Science Institute, Saitama 351-0198, Japan. Dr. Hee Kyung Jin College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, South Korea. Pain and Neural Injury Research Center, MRC, Kyungpook National University, Daegu 702-701, South Korea. After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann– Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.  This paper was cited by:Stem cells for ischemic brain injury: A critical review Terry C. Burns, Catherine M. Verfaillie, Walter C. Low The Journal of Comparative Neurology. Aug 2009, Vol. 515, No. 1: 125-144 CrossRef The Problem of Neuronal Syncytical Connection in Disease O. S. Sotnikov, L. I. Archakova, S. A. Novakovskaya, I. A. Solovyova Bulletin of Experimental Biology and Medicine. Mar 2009, Vol. 147, No. 2: 245-248 CrossRef Extracellular matrix produced by bone marrow stromal cells and by their derivative, SB623 cells, supports neural cell growth Irina Aizman, Ciara C. Tate, Michael McGrogan, Casey C. Case Journal of Neuroscience Research. Feb 2009: NA-NA CrossRef Syncytial coupling of neurons in tissue culture and early ontogenesis O. S. Sotnikov, V. V. Malashko, G. I. Rybakova Neuroscience and Behavioral Physiology. Jun 2008, Vol. 38, No. 4: 323-331 CrossRef Central nervous system therapy for lysosomal storage disorders Gregory M. Enns, Stephen L. Huhn Neurosurgical FOCUS. Apr 2008, Vol. 24, No. 3-4: E12 CrossRef Recruitment of Transplanted Dermal Multipotent Stem Cells to Sites of Injury in Rats with Combined Radiation and Wound Injury by Interaction of SDF-1 and CXCR4 Zhao-Wen Zong, Tian-Min Cheng, Yong-Ping Su, Xin-Ze Ran, Yue Shen, Nan Li, Guo-Ping Ai, Shi-Wu Dong, Hui Xu Radiation Research. Feb 2008, Vol. 170, No. 4: 444 CrossRef Bone Marrow-Derived Mesenchymal Stem Cells Promote Neuronal Networks with Functional Synaptic Transmission After Transplantation into Mice with Neurodegeneration Jae-Sung Bae, Hyung Soo Han, Dong-Ho Youn, Janet E. Carter, Michel Modo, Edward H. Schuchman, Hee Kyung Jin Stem Cells. Jun 2007, Vol. 25, No. 5: 1307-1316 CrossRef Enzyme, cell and gene-based therapies for metachromatic leukodystrophy C. Sevin, P. Aubourg, N. Cartier Journal of Inherited Metabolic Disease. May 2007, Vol. 30, No. 2: 175-183 CrossRef Fusion of nerve fibers O. S. Sotnikov, V. V. Malashko, G. I. Rybakova Doklady Biological Sciences. Nov 2006, Vol. 410, No. 1: 361-363 CrossRef Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis Letizia Mazzini, Katia Mareschi, Ivana Ferrero, Elena Vassallo, Giuseppe Oliveri, Riccardo Boccaletti, Lucia Testa, Sergio Livigni, Franca Fagioli Neurological Research. Aug 2006, Vol. 28, No. 5: 523-526 CrossRef |
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