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Journal of Neurotrauma
Longitudinal Changes in Global Brain Volume between 79 and 409 Days after Traumatic Brain Injury: Relationship with Duration of Coma
To cite this article:
Mehul A. Trivedi, Michael A. Ward, Timothy M. Hess, Shawn D. Gale, Robert J. Dempsey, Howard A. Rowley, Sterling C. Johnson.
Journal of Neurotrauma.
May 2007,
24(5): 766-771.
doi:10.1089/neu.2006.0205.
Mehul A. Trivedi William S. Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center (GRECC), Madison, Wisconsin. Departments of Medicine,University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Michael A. Ward William S. Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center (GRECC), Madison, Wisconsin. Departments of Medicine,University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Timothy M. Hess Departments of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Shawn D. Gale Barrow Neurological Institute, Department of Clinical Neuropsychology, Phoenix, Arizona. Robert J. Dempsey Department of Neurosurgery and University of Wisconsin School of Medicine and Public Health, Medison, Wisconsin. Howard A. Rowley Department of Radiology,University of Wisconsin School of Medicine and Public Health, Medison, Wisconsin. Sterling C. Johnson William S. Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center (GRECC), Madison, Wisconsin. Departments of Medicine,University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Neuropathological and experimental animal studies indicate that traumatic brain injury (TBI) results in long-term, neurodegenerative changes. Structural image evaluation using normalization of atrophy (SIENA) offers an automated analysis of the subtle changes in percent brain volume change (%BVC) associated with TBI. In the present study, SIENA was used to evaluate %BVC in individuals who had sustained a mild to severe TBI. We obtained three-dimensional (3D) T1-weighted anatomical magnetic resonance imaging (MRI) scans approximately 79 days and again 409 days post-injury. TBI patients (n = 37) displayed significantly greater decline in %BVC (−1.43%) relative to a normal comparison group (+0.1%, n = 30). Greater %BVC was associated with longer duration of post-injury coma. These results confirm previous findings from cross-sectional studies and argue that the brain undergoes continued structural change for several months post-injury.  This paper was cited by:Experience of diffusion tensor imaging and 1H spectroscopy for outcome prediction in severe traumatic brain injury: Preliminary results* Eléonore Tollard, Damien Galanaud, Vincent Perlbarg, Paola Sanchez-Pena, Yann Le Fur, Lamine Abdennour, Patrick Cozzone, Stéphane Lehericy, Jacques Chiras, Louis Puybasset Critical Care Medicine. May 2009, Vol. 37, No. 4: 1448-1455 CrossRef Cerebral Atrophy after Traumatic White Matter Injury: Correlation with Acute Neuroimaging and Outcome Kan Ding, Carlos Marquez de la Plata, Jun Yi Wang, Marysa Mumphrey, Carol Moore, Caryn Harper, Christopher J. Madden, Roderick McColl, Anthony Whittemore, Michael D. Devous, Ramon Diaz-Arrastia Journal of Neurotrauma. Dec 2008, Vol. 25, No. 12: 1433-1440 Abstract | Full Text PDF | Reprints & PermissionsExploring impaired consciousness: the MRI approach Damien Galanaud, Lionel Naccache, Louis Puybasset Current Opinion in Neurology. Jan 2008, Vol. 20, No. 6: 627-631 CrossRef |
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