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Rejuvenation Research
Liver Exposure to Xenobiotics: The Aging Factor and Potentials for Functional Foods
To cite this article:
F. Marotta, P. Lecroix, M. Harada, K. Masulair, P. Safran, A. Lorenzetti, S.K. Ono-Nita, P. Marandola.
Rejuvenation Research.
Summer 2006,
9(2): 338-341.
doi:10.1089/rej.2006.9.338.
F. Marotta, M.D., Ph.D.Hepato-Gastroenterology Department, San Giuseppe Hospital, Milan, Italy. GAIA Age-Management Foundation, Pavia, Italy. P. Lecroix Institute Health Care Oriental Medicine, Tokyo, Japan. M. Harada MCH Hospital, Tokyo, Japan. K. Masulair Institute Health Care Oriental Medicine, Tokyo, Japan. P. Safran Institute Health Care Oriental Medicine, Tokyo, Japan. A. Lorenzetti Hepato-Gastroenterology Department, San Giuseppe Hospital, Milan, Italy. S.K. Ono-Nita Hepato-Gastroenterology Department, University of Sao Paulo, Sao Paulo, Brazil. P. Marandola GAIA Age-Management Foundation, Pavia, Italy. Hepatocytes isolated from 20- and 4-month Wistar rats and cultured with or without α-linolenic acid (LNA) were then added with nutraceutical YHK or sylibin before the test with iron or copper. Overall, YHK proved to be more effective than sylibin in Fe/Cu-induced peroxidative damage on normal and LNA-loaded hepatocytes (p < 0.05). YHK exerted a significant protection against DPPH radical-scavenging activity in the "old" group (p versus sylibin) and against lipophilic generators in both age groups (p < 0.05 versus sylibin). Both compounds were ineffective on age-related increase of surface-charge density. These preliminary data suggest that age per se enhances the vulnerability of hepatocytes to xenobiotics, whereas some safe nutraceuticals seem to exert significant protective effects.
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