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Tissue Engineering
Endothelialized Microvasculature Based on a Biodegradable Elastomer
To cite this article:
Christina Fidkowski, Mohammad R. Kaazempur-Mofrad, Jeffrey Borenstein, Joseph P. Vacanti, Robert Langer, Yadong Wang.
Tissue Engineering.
2005,
11(1-2): 302-309.
doi:10.1089/ten.2005.11.302.
Christina Fidkowski, B.S.Division of Health Science and Technology, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Mohammad R. Kaazempur-Mofrad, Ph.D.Department of Mechanical and Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Jeffrey Borenstein, Ph.D.Charles Stark Draper Laboratory, Cambridge, Massachusetts. Joseph P. Vacanti, M.D.Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Robert Langer, Sc.D.Division of Health Science and Technology, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. Yadong Wang, Ph.D.Department of Biomedical Engineering, and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia. Vital organs maintain dense microvasculature to sustain the proper function of their cells. For tissue- engineered organs to function properly, artificial capillary networks must be developed. We have microfabricated capillary networks with a biodegradable and biocompatible elastomer, poly(glycerol sebacate) (PGS). We etched capillary patterns onto silicon wafers by standard microelectromechanical systems (MEMS) techniques. The resultant silicon wafers served as micromolds for the devices. We bond the patterned PGS film with a flat film to create capillary networks that were perfused with a syringe pump at a physiological flow rate. The devices were endothelialized under flow conditions, and part of the lumens reached confluence within 14 days of culture. This approach may lead to tissue-engineered microvasculature that is critical in vital organs engineering.  This paper was cited by:Advanced Material Strategies for Tissue Engineering Scaffolds Lisa E. Freed, George C. Engelmayr, Jeffrey T. Borenstein, Franklin T. Moutos, Farshid Guilak Advanced Materials. 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